scrofulous chow: IV fluids used by NHS responsible for unnecessary deaths

IV fluids used by NHS responsible for unnecessary deaths

Public release date: 27-Feb-2013
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Contact: Katie Steels
press@lshtm.ac.uk
44-020-792-92802
London School of Hygiene & Tropical Medicine

Starch-based intravenous (IV) fluids used by the NHS to treat seriously ill patients are causing unnecessary deaths, according to a new Cochrane systematic review by researchers at the London School of Hygiene & Tropical Medicine.

Based on data from 25 randomised control trials, the researchers concluded that starch-based colloid fluids, used to stabilise patients with low blood pressure, are not only more expensive than saline-based crystalloid fluids, but may also be causing around 250 unnecessary deaths in the UK every year.

The study included 9,147 seriously ill patients after trauma, burns and surgery or those with severe infections who were randomly allocated to receive either colloid fluids or saline fluids in their resuscitation. Those receiving colloids were 10% more likely to die. The researchers are now calling on the NHS to stop using colloid fluids.

Lead author Dr Ian Roberts, director of the clinical trials unit at the London School of Hygiene & Tropical Medicine, said: "Starch solutions are widely used in the NHS and the evidence from our study shows that they kill patients. They are more expensive than saline and they increase the risk of death. British hospitals use far more starch solutions than most other countries. The ongoing use of colloids is unjustified."

The safety of using colloids containing hydroxyethyl starch has been debated for years. They are widely used to treat shock following severe blood loss by increasing blood volume but recent large high quality studies have linked starch use to renal failure. The trials also found more adverse reactions with starch. Crystalloids work in the same way but do not contain starch.

The European Medicines Agency is conducting a review into the safety of hydroxyethyl starch in critically ill patients but Dr Roberts believes that the NHS should take action now and has written to the Department of Health. He said: "We don't need to wait for starch solutions to be banned in order to take action in the NHS. We have a safer, less expensive alternative that is widely used around the world. The NHS should take action now."

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For more information or to request interviews please contact the London School of Hygiene & Tropical Medicine press office.

Notes to Editors:

Perel P, Roberts I, Ker K. Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database of Systematic Reviews 2013, Issue 2. Art. No.: CD000567. DOI: 10.1002/14651858.CD000567.pub6
Paper available pre-embargo to the media from jbeal@wiley.com.
High colloid use in Britain: http://ccforum.com/content/14/5/R185
Calculation for number of deaths: Number of adult admissions to NHS critical care units each year = 115,674 (2010/2011 data from ICNARC case mix programme). Number of patients receiving fluid resuscitation = 42,799. Number of patients receiving colloid = 32,099. Number of patients receiving starch = 12,840. RR of death with STARCH=1.10. Risk of death in unexposed is 20%. For every 50 patients treated there is one extra death. Therefore starch use in British hospitals kill about 12840/50=257 patients each year.
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IV fluids used by NHS responsible for unnecessary deaths Public release date: 27-Feb-2013
[ | E-mail | Share ]
Contact: Katie Steels
press@lshtm.ac.uk
44-020-792-92802
London School of Hygiene & Tropical Medicine